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HIV 1 and 2 Test: What It Shows and What It Does Not


Quick answer: A fourth generation HIV 1 and 2 test looks for both HIV antibodies and the p24 antigen in blood. It can detect HIV earlier than antibody only tests. A positive screening result is confirmed with a second test.

About this test

This blood test detects antibodies to HIV 1 and HIV 2 and p24 antigen, a viral protein that appears early in infection.

Why is it ordered?

  • Routine screening for adults.
  • A new partner or a possible exposure.
  • Pregnancy care.

What results may show

  • A negative result after the window period makes HIV infection unlikely.
  • A reactive result needs confirmation with follow up testing.

What this test may not show

  • A very recent exposure may not be detected. A repeat test after the window period may be advised.
  • A reactive screening result alone is not a diagnosis.
  • It does not measure viral load.
  • It does not test for other infections.

How to prepare

  • No special preparation is needed.
  • Tell your provider about any recent possible exposure so the right timing is used.

Where you can get this test

Option Price Includes
STD Screening Panel, Basic $129 Chlamydia, gonorrhea, syphilis, HIV 1 and 2
STD Screening Panel, Comprehensive $199 Chlamydia, gonorrhea, trichomoniasis, syphilis, HIV 1 and 2, hepatitis B surface antigen, hepatitis C antibody

A doctor’s visit is not required to order. Order online, then visit our Buffalo Grove or Lake Zurich location for the sample. Review results with your own healthcare provider.

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Frequently asked questions

How soon after exposure can the test detect HIV?

Fourth generation tests detect many infections within a few weeks. Your provider can advise on timing and repeat testing.

What does a reactive result mean?

It needs a confirmation test and a visit with a provider. It is not a final diagnosis.

Does it test for other STIs?

No. Other tests cover those.

Sources

  1. MedlinePlus, National Library of Medicine. HIV screening tests.

Medically reviewed by Rodion Levin, FNP-C, Founder and Medical Director. This page is for general education. It does not diagnose a condition or replace advice from your healthcare provider.