TPO Antibodies Test: What It Shows and What It Does Not
Quick answer: A TPO antibody test looks for antibodies against thyroid peroxidase, an enzyme in the thyroid. A positive result can go along with an autoimmune thyroid condition such as Hashimoto disease or Graves disease.
About this test
Thyroid peroxidase (TPO) helps the thyroid make hormone. TPO antibodies are immune proteins that mistakenly target it.
Why is it ordered?
- Looking for a cause of an abnormal TSH or thyroid symptoms.
- Evaluating possible Hashimoto disease or Graves disease.
- Reviewing thyroid health with fertility or pregnancy questions.
What results may show
- A positive result suggests the immune system is acting against the thyroid.
- A higher level can go along with a greater chance of thyroid problems later.
What this test may not show
- Some people have TPO antibodies and normal thyroid function.
- A negative result does not completely rule out autoimmune thyroid disease.
- It does not show how well the thyroid is working. TSH and free T4 do that.
- A positive result alone is not a diagnosis.
How to prepare
- No special preparation is usually needed.
- Tell your provider about thyroid medicine and supplements.
Where you can get this test
| Option | Price | Includes |
|---|---|---|
| Comprehensive Thyroid Panel | $119 | TSH, free T4, free T3, TPO antibodies, thyroglobulin antibodies |
A doctor’s visit is not required to order. Order online, then visit our Buffalo Grove or Lake Zurich location for the sample. Review results with your own healthcare provider.
Related tests
Frequently asked questions
What does a positive TPO antibody test mean?
It suggests an autoimmune process aimed at the thyroid, which your provider reads along with your thyroid function tests.
Can I have TPO antibodies and a normal thyroid?
Yes. Some people do.
How is this different from thyroglobulin antibodies?
They target different thyroid proteins. Both can be positive in autoimmune thyroid disease.
Sources
Medically reviewed by Rodion Levin, FNP-C, Founder and Medical Director. This page is for general education. It does not diagnose a condition or replace advice from your healthcare provider.
